Scanbutazone
Brand names,
Scanbutazone
Analogs
Scanbutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Scanbutazone
Chemical_Formula
C19H20N2O2
Scanbutazone
RX_link
No information avaliable
Scanbutazone
fda sheet
Scanbutazone
msds (material safety sheet)
Scanbutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Scanbutazone
Molecular Weight
308.374 g/mol
Scanbutazone
Melting Point
105 oC
Scanbutazone
H2O Solubility
47.5 mg/L
Scanbutazone
State
Solid
Scanbutazone
LogP
4.214
Scanbutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Scanbutazone
Indication
For the treatment of backache and ankylosing spondylitis
Scanbutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Scanbutazone
Absorption
No information avaliable
Scanbutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Scanbutazone
Patient Information
No information avaliable
Scanbutazone
Organisms Affected
Humans and other mammals