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Phebuzine Brand names, Phebuzine Analogs

Phebuzine Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Phebuzine Chemical_Formula


Phebuzine RX_link

No information avaliable

Phebuzine fda sheet

Phebuzine msds (material safety sheet)

Phebuzine MSDS

Phebuzine Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Phebuzine Molecular Weight

308.374 g/mol

Phebuzine Melting Point

105 oC

Phebuzine H2O Solubility

47.5 mg/L

Phebuzine State


Phebuzine LogP


Phebuzine Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Phebuzine Indication

For the treatment of backache and ankylosing spondylitis

Phebuzine Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Phebuzine Absorption

No information avaliable

Phebuzine side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Phebuzine Patient Information

No information avaliable

Phebuzine Organisms Affected

Humans and other mammals