Mepha-Butazon
Brand names,
Mepha-Butazon
Analogs
Mepha-Butazon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Mepha-Butazon
Chemical_Formula
C19H20N2O2
Mepha-Butazon
RX_link
No information avaliable
Mepha-Butazon
fda sheet
Mepha-Butazon
msds (material safety sheet)
Mepha-Butazon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Mepha-Butazon
Molecular Weight
308.374 g/mol
Mepha-Butazon
Melting Point
105 oC
Mepha-Butazon
H2O Solubility
47.5 mg/L
Mepha-Butazon
State
Solid
Mepha-Butazon
LogP
4.214
Mepha-Butazon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Mepha-Butazon
Indication
For the treatment of backache and ankylosing spondylitis
Mepha-Butazon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Mepha-Butazon
Absorption
No information avaliable
Mepha-Butazon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Mepha-Butazon
Patient Information
No information avaliable
Mepha-Butazon
Organisms Affected
Humans and other mammals