Butapirazole
Brand names,
Butapirazole
Analogs
Butapirazole
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butapirazole
Chemical_Formula
C19H20N2O2
Butapirazole
RX_link
No information avaliable
Butapirazole
fda sheet
Butapirazole
msds (material safety sheet)
Butapirazole
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butapirazole
Molecular Weight
308.374 g/mol
Butapirazole
Melting Point
105 oC
Butapirazole
H2O Solubility
47.5 mg/L
Butapirazole
State
Solid
Butapirazole
LogP
4.214
Butapirazole
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butapirazole
Indication
For the treatment of backache and ankylosing spondylitis
Butapirazole
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butapirazole
Absorption
No information avaliable
Butapirazole
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butapirazole
Patient Information
No information avaliable
Butapirazole
Organisms Affected
Humans and other mammals