Bizolin
Brand names,
Bizolin
Analogs
Bizolin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Bizolin
Chemical_Formula
C19H20N2O2
Bizolin
RX_link
No information avaliable
Bizolin
fda sheet
Bizolin
msds (material safety sheet)
Bizolin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Bizolin
Molecular Weight
308.374 g/mol
Bizolin
Melting Point
105 oC
Bizolin
H2O Solubility
47.5 mg/L
Bizolin
State
Solid
Bizolin
LogP
4.214
Bizolin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Bizolin
Indication
For the treatment of backache and ankylosing spondylitis
Bizolin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Bizolin
Absorption
No information avaliable
Bizolin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Bizolin
Patient Information
No information avaliable
Bizolin
Organisms Affected
Humans and other mammals