Butacote
Brand names,
Butacote
Analogs
Butacote
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butacote
Chemical_Formula
C19H20N2O2
Butacote
RX_link
No information avaliable
Butacote
fda sheet
Butacote
msds (material safety sheet)
Butacote
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butacote
Molecular Weight
308.374 g/mol
Butacote
Melting Point
105 oC
Butacote
H2O Solubility
47.5 mg/L
Butacote
State
Solid
Butacote
LogP
4.214
Butacote
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butacote
Indication
For the treatment of backache and ankylosing spondylitis
Butacote
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butacote
Absorption
No information avaliable
Butacote
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butacote
Patient Information
No information avaliable
Butacote
Organisms Affected
Humans and other mammals