Butalgin
Brand names,
Butalgin
Analogs
Butalgin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butalgin
Chemical_Formula
C19H20N2O2
Butalgin
RX_link
No information avaliable
Butalgin
fda sheet
Butalgin
msds (material safety sheet)
Butalgin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butalgin
Molecular Weight
308.374 g/mol
Butalgin
Melting Point
105 oC
Butalgin
H2O Solubility
47.5 mg/L
Butalgin
State
Solid
Butalgin
LogP
4.214
Butalgin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butalgin
Indication
For the treatment of backache and ankylosing spondylitis
Butalgin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butalgin
Absorption
No information avaliable
Butalgin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butalgin
Patient Information
No information avaliable
Butalgin
Organisms Affected
Humans and other mammals