Antadol

Material Safety Data Sheet
Phenylbutazone, 99+%

ACC# 17417

Section 1 - Chemical Product and Company Identification

MSDS Name: Phenylbutazone, 99+%
Catalog Numbers: AC199310000, AC199310050, AC199311000
Synonyms: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione; Butadione; Diphenylbutazone.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300

Section 2 - Composition, Information on Ingredients

CAS#	Chemical Name	Percent	EINECS/ELINCS
50-33-9	Phenylbutazone	99.0+	200-029-0

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: white powder.
Warning! May cause kidney tubule and glomeruli damage. Harmful if swallowed. Causes eye and skin irritation. Causes digestive and respiratory tract irritation.
Target Organs: None.

Potential Health Effects
Eye: Causes eye irritation.
Skin: Causes skin irritation.
Ingestion: Harmful if swallowed. Causes digestive tract irritation. Ingestion may cause fever, blood pressure increase and other unspecified vascular effects.
Inhalation: Causes respiratory tract irritation.
Chronic: Damage to kidney tubules or glomeruli may occur.

Section 4 - First Aid Measures

Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:N/A
Upper: N/A
NFPA Rating: (estimated) Health: 2; Flammability: ; Instability: 0

Section 6 - Accidental Release Measures

General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Section 7 - Handling and Storage

Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.
Storage: Store in a cool, dry place. Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - Exposure Controls, Personal Protection

Engineering Controls: Use adequate ventilation to keep airborne concentrations low.
Exposure Limits

Chemical Name	ACGIH	NIOSH	OSHA - Final PELs
Phenylbutazone	none listed	none listed	none listed

OSHA Vacated PELs: Phenylbutazone: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

Section 9 - Physical and Chemical Properties

Physical State: Powder
Appearance: white
Odor: odorless - very slight aromatic odor
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:106 - 108 deg C
Decomposition Temperature:Not available.
Solubility: soluable @22.5C
Specific Gravity/Density:Not available.
Molecular Formula:C19H20N2O2
Molecular Weight:308.38

Section 10 - Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, dust generation, strong oxidants.
Incompatibilities with Other Materials: Strong oxidizing agents - strong acids - strong bases.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information

RTECS#:
CAS# 50-33-9: UQ8225000
LD50/LC50:
CAS# 50-33-9:
     Draize test, rabbit, eye: 100 mg Moderate;
     Oral, mouse: LD50 = 238 mg/kg;
     Oral, rabbit: LD50 = 781 mg/kg;
     Oral, rat: LD50 = 245 mg/kg;
     Oral, rat: LD50 = 375 mg/kg;
.

Carcinogenicity:
CAS# 50-33-9: Not listed by ACGIH, IARC, NTP, or CA Prop 65.

Epidemiology: TDLo,Human(Woman)=40mg/kg; Agranulocytosis, leukopenia in blodd.
Teratogenicity: TDLo,Oral,Rat=13gm/kg; changes in liver weight. TDLo,Oral,Human=17,500ug/kg; changes in ureter,bladder tubules, urine volume decreased.
Reproductive Effects: Experimental reproductive effects.TDLo,Oral,Rat=360mg/kg;causes parturition. TDLo,Oral,Rat=30 mg/kg; specific developmental abnormalities, cardiovascular system. TDLo,Oral,Rat=600 mg/kg; effects on embryo or fetus-fetotoxicity.
Mutagenicity: Human mutation data reported. Mutation Test Systems,Human Embryo=20mg/L,Human Lymphocyte=320umol/L. Cytogenetic analysis, Human Lymphocytes=320 umol/L.
Neurotoxicity: No information found.
Other Studies:

Section 12 - Ecological Information

Ecotoxicity: No data available. No information available.
Environmental: No information found.
Physical: No information found.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

	US DOT	Canada TDG
Shipping Name:	Not regulated as a hazardous material	No information available.
Hazard Class:
UN Number:
Packing Group:

Section 15 - Regulatory Information

US FEDERAL

TSCA
     CAS# 50-33-9 is listed on the TSCA inventory.
Health & Safety Reporting List
     None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
     None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
     None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
     None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
     None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
     None of the chemicals in this product have a TPQ.
Section 313      No chemicals are reportable under Section 313.
Clean Air Act:
     This material does not contain any hazardous air pollutants.
     This material does not contain any Class 1 Ozone depletors.
     This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
     None of the chemicals in this product are listed as Hazardous Substances under the CWA.
     None of the chemicals in this product are listed as Priority Pollutants under the CWA.
     None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
     None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
     CAS# 50-33-9 is not present on state lists from CA, PA, MN, MA, FL, or NJ.

California Prop 65

California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
     XN
Risk Phrases:
     R 22 Harmful if swallowed.
     R 36/37/38 Irritating to eyes, respiratory system and skin.

Safety Phrases:
     S 26 In case of contact with eyes, rinse immediately with plenty of
     water and seek medical advice.
     S 37/39 Wear suitable gloves and eye/face protection.

WGK (Water Danger/Protection)
     CAS# 50-33-9: 2
Canada - DSL/NDSL
     CAS# 50-33-9 is listed on Canada's DSL List.
Canada - WHMIS
     WHMIS: Not available.
This product has been classified in accordance with the hazard criteria of the Controlled Products Regulations and the MSDS contains all of the information required by those regulations.
Canadian Ingredient Disclosure List

Section 16 - Additional Information

MSDS Creation Date: 11/20/1998
Revision #3 Date: 10/03/2005

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.