Diphenylbutazone
Material Safety Data Sheet
Phenylbutazone, 99+%
ACC# 17417
Section 1 - Chemical Product and Company Identification |
MSDS Name: Phenylbutazone, 99+%
Catalog Numbers:
AC199310000, AC199310050, AC199311000
Synonyms:
4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione; Butadione;
Diphenylbutazone.
Company Identification:
Acros Organics N.V.
One Reagent Lane
Fair Lawn, NJ 07410
For information in North America, call: 800-ACROS-01
For emergencies in the US, call CHEMTREC: 800-424-9300
Section 2 - Composition, Information on Ingredients
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CAS# |
Chemical Name |
Percent |
EINECS/ELINCS |
50-33-9 |
Phenylbutazone |
99.0+ | 200-029-0 |
Section 3 - Hazards Identification
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EMERGENCY OVERVIEW
Appearance: white powder.
Warning! May cause kidney tubule and glomeruli
damage. Harmful if swallowed. Causes eye and skin irritation. Causes
digestive and respiratory tract irritation.
Target Organs: None.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation.
Ingestion:
Harmful if swallowed. Causes digestive tract irritation. Ingestion
may cause fever, blood pressure increase and other unspecified
vascular effects.
Inhalation:
Causes respiratory tract irritation.
Chronic:
Damage to kidney tubules or glomeruli may occur.
Section 4 - First Aid Measures
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Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally
lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15
minutes while removing contaminated clothing and shoes. Wash clothing
before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical
aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not
breathing, give artificial respiration. If breathing is difficult,
give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.
Section 5 - Fire Fighting Measures
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General Information:
As in any fire, wear a self-contained breathing apparatus in
pressure-demand, MSHA/NIOSH (approved or equivalent), and full
protective gear. During a fire, irritating and highly toxic gases
may be generated by thermal decomposition or combustion.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or
alcohol-resistant foam.
Flash Point: Not applicable.
Autoignition Temperature: Not applicable.
Explosion Limits, Lower:N/A
Upper: N/A
NFPA Rating:
(estimated) Health: 2; Flammability: ; Instability: 0
Section 6 - Accidental Release Measures
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General Information: Use proper personal protective equipment as indicated
in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective
Equipment section. Sweep up or absorb material, then place into a
suitable clean, dry, closed container for disposal. Avoid generating
dusty conditions. Provide ventilation.
Section 7 - Handling and Storage
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Handling:
Wash thoroughly after handling. Remove contaminated clothing and
wash before reuse. Minimize dust generation and accumulation. Avoid
contact with eyes, skin, and clothing. Keep container tightly closed.
Avoid ingestion and inhalation. Use with adequate ventilation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a cool, dry, well-ventilated area away from incompatible
substances.
Section 8 - Exposure Controls, Personal Protection
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Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Exposure Limits
Chemical Name |
ACGIH |
NIOSH |
OSHA - Final PELs |
Phenylbutazone
|
none listed
|
none listed
|
none listed
|
OSHA Vacated PELs:
Phenylbutazone:
No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical
safety goggles as described by OSHA's eye and face
protection regulations in 29 CFR 1910.133 or European
Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin
exposure.
Clothing:
Wear appropriate protective clothing to prevent skin
exposure.
Respirators:
A respiratory protection program that meets OSHA's 29
CFR 1910.134 and ANSI Z88.2 requirements or European
Standard EN 149 must be followed whenever workplace
conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
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Physical State: Powder
Appearance: white
Odor: odorless - very slight aromatic odor
pH: Not available.
Vapor Pressure: Not available.
Vapor Density: Not available.
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point:106 - 108 deg C
Decomposition Temperature:Not available.
Solubility: soluable @22.5C
Specific Gravity/Density:Not available.
Molecular Formula:C19H20N2O2
Molecular Weight:308.38
Section 10 - Stability and Reactivity
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Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents - strong acids - strong bases.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and
gases, carbon dioxide, nitrogen.
Hazardous Polymerization: Has not been reported.
Section 11 - Toxicological Information
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RTECS#:
CAS# 50-33-9:
UQ8225000
LD50/LC50:
CAS# 50-33-9:
Draize test, rabbit,
eye: 100 mg Moderate;
Oral, mouse:
LD50 = 238 mg/kg;
Oral, rabbit:
LD50 = 781 mg/kg;
Oral, rat: LD50
= 245 mg/kg;
Oral, rat: LD50 = 375
mg/kg;
.
Carcinogenicity:
CAS# 50-33-9:
Not listed by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology:
TDLo,Human(Woman)=40mg/kg; Agranulocytosis, leukopenia in
blodd.
Teratogenicity:
TDLo,Oral,Rat=13gm/kg; changes in liver weight.
TDLo,Oral,Human=17,500ug/kg; changes in ureter,bladder
tubules, urine volume decreased.
Reproductive Effects:
Experimental reproductive
effects.TDLo,Oral,Rat=360mg/kg;causes parturition.
TDLo,Oral,Rat=30 mg/kg; specific developmental
abnormalities, cardiovascular system. TDLo,Oral,Rat=600
mg/kg; effects on embryo or fetus-fetotoxicity.
Mutagenicity:
Human mutation data reported. Mutation Test Systems,Human
Embryo=20mg/L,Human Lymphocyte=320umol/L. Cytogenetic
analysis, Human Lymphocytes=320 umol/L.
Neurotoxicity:
No information found.
Other Studies:
Section 12 - Ecological Information
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Ecotoxicity:
No data available.
No information available.
Environmental:
No information found.
Physical:
No information found.
Other:
No information available.
Section 13 - Disposal Considerations
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Chemical waste generators must determine whether a discarded chemical is classified
as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous waste regulations to
ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.
Section 14 - Transport Information
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US DOT |
Canada TDG |
Shipping Name: |
Not regulated as a hazardous material |
No information available. |
Hazard Class: |
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UN Number: |
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Packing Group: |
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Section 15 - Regulatory Information
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US FEDERAL
TSCA
CAS# 50-33-9 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
CERCLA Hazardous Substances and corresponding RQs
None of the chemicals in this material have an RQ.
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants.
This material does not contain any Class 1 Ozone depletors.
This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product
are listed as Hazardous Substances under the CWA.
None of the chemicals in this
product are listed as Priority Pollutants under the CWA.
None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product
are considered highly hazardous by OSHA.
STATE
CAS# 50-33-9 is not present on
state lists from CA, PA, MN, MA, FL, or NJ.
California Prop 65
California No Significant Risk Level:
None of the chemicals in this product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of
water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face protection.
WGK (Water Danger/Protection)
CAS# 50-33-9: 2
Canada - DSL/NDSL
CAS# 50-33-9 is listed on Canada's DSL List.
Canada - WHMIS
WHMIS: Not available.
This product has been classified in accordance with the hazard
criteria of the Controlled Products Regulations and the MSDS
contains all of the information required by those regulations.
Canadian Ingredient Disclosure List
Section 16 - Additional Information
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MSDS Creation Date: 11/20/1998
Revision #3 Date: 10/03/2005
The information above is believed to be accurate and represents the best
information currently available to us. However, we make no warranty of
merchantability or any other warranty, express or implied, with respect to
such information, and we assume no liability resulting from its use. Users
should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall Fisher be liable
for any claims, losses, or damages of any third party or for lost profits
or any special, indirect, incidental, consequential or exemplary
damages, howsoever arising, even if Fisher has been advised of
the possibility of such damages.