Labetalol
Brand names,
Labetalol
Analogs
Labetalol
Brand Names Mixture
Labetalol
Chemical_Formula
C19H24N2O3
Labetalol
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Labetalol
fda sheet
Labetalol
msds (material safety sheet)
Labetalol
Synthesis Reference
No information avaliable
Labetalol
Molecular Weight
328.406 g/mol
Labetalol
Melting Point
195-196 oC
Labetalol
H2O Solubility
20 mg/ml (HCl salt)
Labetalol
State
Solid
Labetalol
LogP
2.868
Labetalol
Dosage Forms
Liquid; Tablet
Labetalol
Indication
For the management of hypertension.
Labetalol
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Labetalol
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Labetalol
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Labetalol
Patient Information
Labetalol
Organisms Affected
Humans and other mammals