Isonicotinoyl hydrazide
Brand names,
Isonicotinoyl hydrazide
Analogs
Isonicotinoyl hydrazide
Brand Names Mixture
Isonicotinoyl hydrazide
Chemical_Formula
C19H24N2O3
Isonicotinoyl hydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinoyl hydrazide
fda sheet
Isonicotinoyl hydrazide
msds (material safety sheet)
Isonicotinoyl hydrazide
Synthesis Reference
No information avaliable
Isonicotinoyl hydrazide
Molecular Weight
328.406 g/mol
Isonicotinoyl hydrazide
Melting Point
195-196 oC
Isonicotinoyl hydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinoyl hydrazide
State
Solid
Isonicotinoyl hydrazide
LogP
2.868
Isonicotinoyl hydrazide
Dosage Forms
Liquid; Tablet
Isonicotinoyl hydrazide
Indication
For the management of hypertension.
Isonicotinoyl hydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinoyl hydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinoyl hydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinoyl hydrazide
Patient Information
Isonicotinoyl hydrazide
Organisms Affected
Humans and other mammals