TB-Razide
Brand names,
TB-Razide
Analogs
TB-Razide
Brand Names Mixture
TB-Razide
Chemical_Formula
C19H24N2O3
TB-Razide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
TB-Razide
fda sheet
TB-Razide
msds (material safety sheet)
TB-Razide
Synthesis Reference
No information avaliable
TB-Razide
Molecular Weight
328.406 g/mol
TB-Razide
Melting Point
195-196 oC
TB-Razide
H2O Solubility
20 mg/ml (HCl salt)
TB-Razide
State
Solid
TB-Razide
LogP
2.868
TB-Razide
Dosage Forms
Liquid; Tablet
TB-Razide
Indication
For the management of hypertension.
TB-Razide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
TB-Razide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
TB-Razide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
TB-Razide
Patient Information
TB-Razide
Organisms Affected
Humans and other mammals