Nicetal
Brand names,
Nicetal
Analogs
Nicetal
Brand Names Mixture
Nicetal
Chemical_Formula
C19H24N2O3
Nicetal
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nicetal
fda sheet
Nicetal
msds (material safety sheet)
Nicetal
Synthesis Reference
No information avaliable
Nicetal
Molecular Weight
328.406 g/mol
Nicetal
Melting Point
195-196 oC
Nicetal
H2O Solubility
20 mg/ml (HCl salt)
Nicetal
State
Solid
Nicetal
LogP
2.868
Nicetal
Dosage Forms
Liquid; Tablet
Nicetal
Indication
For the management of hypertension.
Nicetal
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nicetal
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Nicetal
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Nicetal
Patient Information
Nicetal
Organisms Affected
Humans and other mammals