Antituberkulosum
Brand names,
Antituberkulosum
Analogs
Antituberkulosum
Brand Names Mixture
Antituberkulosum
Chemical_Formula
C19H24N2O3
Antituberkulosum
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Antituberkulosum
fda sheet
Antituberkulosum
msds (material safety sheet)
Antituberkulosum
Synthesis Reference
No information avaliable
Antituberkulosum
Molecular Weight
328.406 g/mol
Antituberkulosum
Melting Point
195-196 oC
Antituberkulosum
H2O Solubility
20 mg/ml (HCl salt)
Antituberkulosum
State
Solid
Antituberkulosum
LogP
2.868
Antituberkulosum
Dosage Forms
Liquid; Tablet
Antituberkulosum
Indication
For the management of hypertension.
Antituberkulosum
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Antituberkulosum
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Antituberkulosum
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Antituberkulosum
Patient Information
Antituberkulosum
Organisms Affected
Humans and other mammals