Ismazide
Brand names,
Ismazide
Analogs
Ismazide
Brand Names Mixture
Ismazide
Chemical_Formula
C19H24N2O3
Ismazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Ismazide
fda sheet
Ismazide
msds (material safety sheet)
Ismazide
Synthesis Reference
No information avaliable
Ismazide
Molecular Weight
328.406 g/mol
Ismazide
Melting Point
195-196 oC
Ismazide
H2O Solubility
20 mg/ml (HCl salt)
Ismazide
State
Solid
Ismazide
LogP
2.868
Ismazide
Dosage Forms
Liquid; Tablet
Ismazide
Indication
For the management of hypertension.
Ismazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Ismazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Ismazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Ismazide
Patient Information
Ismazide
Organisms Affected
Humans and other mammals