Rimiphone
Brand names,
Rimiphone
Analogs
Rimiphone
Brand Names Mixture
Rimiphone
Chemical_Formula
C19H24N2O3
Rimiphone
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Rimiphone
fda sheet
Rimiphone
msds (material safety sheet)
Rimiphone
Synthesis Reference
No information avaliable
Rimiphone
Molecular Weight
328.406 g/mol
Rimiphone
Melting Point
195-196 oC
Rimiphone
H2O Solubility
20 mg/ml (HCl salt)
Rimiphone
State
Solid
Rimiphone
LogP
2.868
Rimiphone
Dosage Forms
Liquid; Tablet
Rimiphone
Indication
For the management of hypertension.
Rimiphone
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Rimiphone
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Rimiphone
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Rimiphone
Patient Information
Rimiphone
Organisms Affected
Humans and other mammals