Isotebe
Brand names,
Isotebe
Analogs
Isotebe
Brand Names Mixture
Isotebe
Chemical_Formula
C19H24N2O3
Isotebe
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isotebe
fda sheet
Isotebe
msds (material safety sheet)
Isotebe
Synthesis Reference
No information avaliable
Isotebe
Molecular Weight
328.406 g/mol
Isotebe
Melting Point
195-196 oC
Isotebe
H2O Solubility
20 mg/ml (HCl salt)
Isotebe
State
Solid
Isotebe
LogP
2.868
Isotebe
Dosage Forms
Liquid; Tablet
Isotebe
Indication
For the management of hypertension.
Isotebe
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isotebe
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isotebe
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isotebe
Patient Information
Isotebe
Organisms Affected
Humans and other mammals