Isonicotinyl hydrazide
Brand names,
Isonicotinyl hydrazide
Analogs
Isonicotinyl hydrazide
Brand Names Mixture
Isonicotinyl hydrazide
Chemical_Formula
C19H24N2O3
Isonicotinyl hydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinyl hydrazide
fda sheet
Isonicotinyl hydrazide
msds (material safety sheet)
Isonicotinyl hydrazide
Synthesis Reference
No information avaliable
Isonicotinyl hydrazide
Molecular Weight
328.406 g/mol
Isonicotinyl hydrazide
Melting Point
195-196 oC
Isonicotinyl hydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinyl hydrazide
State
Solid
Isonicotinyl hydrazide
LogP
2.868
Isonicotinyl hydrazide
Dosage Forms
Liquid; Tablet
Isonicotinyl hydrazide
Indication
For the management of hypertension.
Isonicotinyl hydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinyl hydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinyl hydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinyl hydrazide
Patient Information
Isonicotinyl hydrazide
Organisms Affected
Humans and other mammals