Neoteben
Brand names,
Neoteben
Analogs
Neoteben
Brand Names Mixture
Neoteben
Chemical_Formula
C19H24N2O3
Neoteben
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Neoteben
fda sheet
Neoteben
msds (material safety sheet)
Neoteben
Synthesis Reference
No information avaliable
Neoteben
Molecular Weight
328.406 g/mol
Neoteben
Melting Point
195-196 oC
Neoteben
H2O Solubility
20 mg/ml (HCl salt)
Neoteben
State
Solid
Neoteben
LogP
2.868
Neoteben
Dosage Forms
Liquid; Tablet
Neoteben
Indication
For the management of hypertension.
Neoteben
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Neoteben
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Neoteben
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Neoteben
Patient Information
Neoteben
Organisms Affected
Humans and other mammals