Nitebannsc 9659
Brand names,
Nitebannsc 9659
Analogs
Nitebannsc 9659
Brand Names Mixture
Nitebannsc 9659
Chemical_Formula
C19H24N2O3
Nitebannsc 9659
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nitebannsc 9659
fda sheet
Nitebannsc 9659
msds (material safety sheet)
Nitebannsc 9659
Synthesis Reference
No information avaliable
Nitebannsc 9659
Molecular Weight
328.406 g/mol
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Melting Point
195-196 oC
Nitebannsc 9659
H2O Solubility
20 mg/ml (HCl salt)
Nitebannsc 9659
State
Solid
Nitebannsc 9659
LogP
2.868
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Dosage Forms
Liquid; Tablet
Nitebannsc 9659
Indication
For the management of hypertension.
Nitebannsc 9659
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nitebannsc 9659
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
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side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
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Patient Information
Nitebannsc 9659
Organisms Affected
Humans and other mammals