Isonicotinhydrazid
Brand names,
Isonicotinhydrazid
Analogs
Isonicotinhydrazid
Brand Names Mixture
Isonicotinhydrazid
Chemical_Formula
C19H24N2O3
Isonicotinhydrazid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinhydrazid
fda sheet
Isonicotinhydrazid
msds (material safety sheet)
Isonicotinhydrazid
Synthesis Reference
No information avaliable
Isonicotinhydrazid
Molecular Weight
328.406 g/mol
Isonicotinhydrazid
Melting Point
195-196 oC
Isonicotinhydrazid
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinhydrazid
State
Solid
Isonicotinhydrazid
LogP
2.868
Isonicotinhydrazid
Dosage Forms
Liquid; Tablet
Isonicotinhydrazid
Indication
For the management of hypertension.
Isonicotinhydrazid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinhydrazid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinhydrazid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinhydrazid
Patient Information
Isonicotinhydrazid
Organisms Affected
Humans and other mammals