Pyreazid
Brand names,
Pyreazid
Analogs
Pyreazid
Brand Names Mixture
Pyreazid
Chemical_Formula
C19H24N2O3
Pyreazid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Pyreazid
fda sheet
Pyreazid
msds (material safety sheet)
Pyreazid
Synthesis Reference
No information avaliable
Pyreazid
Molecular Weight
328.406 g/mol
Pyreazid
Melting Point
195-196 oC
Pyreazid
H2O Solubility
20 mg/ml (HCl salt)
Pyreazid
State
Solid
Pyreazid
LogP
2.868
Pyreazid
Dosage Forms
Liquid; Tablet
Pyreazid
Indication
For the management of hypertension.
Pyreazid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Pyreazid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Pyreazid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Pyreazid
Patient Information
Pyreazid
Organisms Affected
Humans and other mammals