Nicotibine
Brand names,
Nicotibine
Analogs
Nicotibine
Brand Names Mixture
Nicotibine
Chemical_Formula
C19H24N2O3
Nicotibine
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nicotibine
fda sheet
Nicotibine
msds (material safety sheet)
Nicotibine
Synthesis Reference
No information avaliable
Nicotibine
Molecular Weight
328.406 g/mol
Nicotibine
Melting Point
195-196 oC
Nicotibine
H2O Solubility
20 mg/ml (HCl salt)
Nicotibine
State
Solid
Nicotibine
LogP
2.868
Nicotibine
Dosage Forms
Liquid; Tablet
Nicotibine
Indication
For the management of hypertension.
Nicotibine
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nicotibine
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Nicotibine
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Nicotibine
Patient Information
Nicotibine
Organisms Affected
Humans and other mammals