Defonin
Brand names,
Defonin
Analogs
Defonin
Brand Names Mixture
Defonin
Chemical_Formula
C19H24N2O3
Defonin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Defonin
fda sheet
Defonin
msds (material safety sheet)
Defonin
Synthesis Reference
No information avaliable
Defonin
Molecular Weight
328.406 g/mol
Defonin
Melting Point
195-196 oC
Defonin
H2O Solubility
20 mg/ml (HCl salt)
Defonin
State
Solid
Defonin
LogP
2.868
Defonin
Dosage Forms
Liquid; Tablet
Defonin
Indication
For the management of hypertension.
Defonin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Defonin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Defonin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Defonin
Patient Information
Defonin
Organisms Affected
Humans and other mammals