Isonindon
Brand names,
Isonindon
Analogs
Isonindon
Brand Names Mixture
Isonindon
Chemical_Formula
C19H24N2O3
Isonindon
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonindon
fda sheet
Isonindon
msds (material safety sheet)
Isonindon
Synthesis Reference
No information avaliable
Isonindon
Molecular Weight
328.406 g/mol
Isonindon
Melting Point
195-196 oC
Isonindon
H2O Solubility
20 mg/ml (HCl salt)
Isonindon
State
Solid
Isonindon
LogP
2.868
Isonindon
Dosage Forms
Liquid; Tablet
Isonindon
Indication
For the management of hypertension.
Isonindon
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonindon
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonindon
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonindon
Patient Information
Isonindon
Organisms Affected
Humans and other mammals