Isonin
Brand names,
Isonin
Analogs
Isonin
Brand Names Mixture
Isonin
Chemical_Formula
C19H24N2O3
Isonin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonin
fda sheet
Isonin
msds (material safety sheet)
Isonin
Synthesis Reference
No information avaliable
Isonin
Molecular Weight
328.406 g/mol
Isonin
Melting Point
195-196 oC
Isonin
H2O Solubility
20 mg/ml (HCl salt)
Isonin
State
Solid
Isonin
LogP
2.868
Isonin
Dosage Forms
Liquid; Tablet
Isonin
Indication
For the management of hypertension.
Isonin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonin
Patient Information
Isonin
Organisms Affected
Humans and other mammals