Nicizina
Brand names,
Nicizina
Analogs
Nicizina
Brand Names Mixture
Nicizina
Chemical_Formula
C19H24N2O3
Nicizina
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nicizina
fda sheet
Nicizina
msds (material safety sheet)
Nicizina
Synthesis Reference
No information avaliable
Nicizina
Molecular Weight
328.406 g/mol
Nicizina
Melting Point
195-196 oC
Nicizina
H2O Solubility
20 mg/ml (HCl salt)
Nicizina
State
Solid
Nicizina
LogP
2.868
Nicizina
Dosage Forms
Liquid; Tablet
Nicizina
Indication
For the management of hypertension.
Nicizina
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nicizina
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Nicizina
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Nicizina
Patient Information
Nicizina
Organisms Affected
Humans and other mammals