Dibutin
Brand names,
Dibutin
Analogs
Dibutin
Brand Names Mixture
Dibutin
Chemical_Formula
C19H24N2O3
Dibutin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Dibutin
fda sheet
Dibutin
msds (material safety sheet)
Dibutin
Synthesis Reference
No information avaliable
Dibutin
Molecular Weight
328.406 g/mol
Dibutin
Melting Point
195-196 oC
Dibutin
H2O Solubility
20 mg/ml (HCl salt)
Dibutin
State
Solid
Dibutin
LogP
2.868
Dibutin
Dosage Forms
Liquid; Tablet
Dibutin
Indication
For the management of hypertension.
Dibutin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Dibutin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Dibutin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Dibutin
Patient Information
Dibutin
Organisms Affected
Humans and other mammals