Isonidrin
Brand names,
Isonidrin
Analogs
Isonidrin
Brand Names Mixture
Isonidrin
Chemical_Formula
C19H24N2O3
Isonidrin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonidrin
fda sheet
Isonidrin
msds (material safety sheet)
Isonidrin
Synthesis Reference
No information avaliable
Isonidrin
Molecular Weight
328.406 g/mol
Isonidrin
Melting Point
195-196 oC
Isonidrin
H2O Solubility
20 mg/ml (HCl salt)
Isonidrin
State
Solid
Isonidrin
LogP
2.868
Isonidrin
Dosage Forms
Liquid; Tablet
Isonidrin
Indication
For the management of hypertension.
Isonidrin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonidrin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonidrin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonidrin
Patient Information
Isonidrin
Organisms Affected
Humans and other mammals