Isohydrazide
Brand names,
Isohydrazide
Analogs
Isohydrazide
Brand Names Mixture
Isohydrazide
Chemical_Formula
C19H24N2O3
Isohydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isohydrazide
fda sheet
Isohydrazide
msds (material safety sheet)
Isohydrazide
Synthesis Reference
No information avaliable
Isohydrazide
Molecular Weight
328.406 g/mol
Isohydrazide
Melting Point
195-196 oC
Isohydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isohydrazide
State
Solid
Isohydrazide
LogP
2.868
Isohydrazide
Dosage Forms
Liquid; Tablet
Isohydrazide
Indication
For the management of hypertension.
Isohydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isohydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isohydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isohydrazide
Patient Information
Isohydrazide
Organisms Affected
Humans and other mammals