FSR 3
Brand names,
FSR 3
Analogs
FSR 3
Brand Names Mixture
FSR 3
Chemical_Formula
C19H24N2O3
FSR 3
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
FSR 3
fda sheet
FSR 3
msds (material safety sheet)
FSR 3
Synthesis Reference
No information avaliable
FSR 3
Molecular Weight
328.406 g/mol
FSR 3
Melting Point
195-196 oC
FSR 3
H2O Solubility
20 mg/ml (HCl salt)
FSR 3
State
Solid
FSR 3
LogP
2.868
FSR 3
Dosage Forms
Liquid; Tablet
FSR 3
Indication
For the management of hypertension.
FSR 3
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
FSR 3
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
FSR 3
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
FSR 3
Patient Information
FSR 3
Organisms Affected
Humans and other mammals