Isopyrin
Brand names,
Isopyrin
Analogs
Isopyrin
Brand Names Mixture
Isopyrin
Chemical_Formula
C19H24N2O3
Isopyrin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isopyrin
fda sheet
Isopyrin
msds (material safety sheet)
Isopyrin
Synthesis Reference
No information avaliable
Isopyrin
Molecular Weight
328.406 g/mol
Isopyrin
Melting Point
195-196 oC
Isopyrin
H2O Solubility
20 mg/ml (HCl salt)
Isopyrin
State
Solid
Isopyrin
LogP
2.868
Isopyrin
Dosage Forms
Liquid; Tablet
Isopyrin
Indication
For the management of hypertension.
Isopyrin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isopyrin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isopyrin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isopyrin
Patient Information
Isopyrin
Organisms Affected
Humans and other mammals