Isonicid
Brand names,
Isonicid
Analogs
Isonicid
Brand Names Mixture
Isonicid
Chemical_Formula
C19H24N2O3
Isonicid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicid
fda sheet
Isonicid
msds (material safety sheet)
Isonicid
Synthesis Reference
No information avaliable
Isonicid
Molecular Weight
328.406 g/mol
Isonicid
Melting Point
195-196 oC
Isonicid
H2O Solubility
20 mg/ml (HCl salt)
Isonicid
State
Solid
Isonicid
LogP
2.868
Isonicid
Dosage Forms
Liquid; Tablet
Isonicid
Indication
For the management of hypertension.
Isonicid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicid
Patient Information
Isonicid
Organisms Affected
Humans and other mammals