Atcotibine
Brand names,
Atcotibine
Analogs
Atcotibine
Brand Names Mixture
Atcotibine
Chemical_Formula
C19H24N2O3
Atcotibine
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Atcotibine
fda sheet
Atcotibine
msds (material safety sheet)
Atcotibine
Synthesis Reference
No information avaliable
Atcotibine
Molecular Weight
328.406 g/mol
Atcotibine
Melting Point
195-196 oC
Atcotibine
H2O Solubility
20 mg/ml (HCl salt)
Atcotibine
State
Solid
Atcotibine
LogP
2.868
Atcotibine
Dosage Forms
Liquid; Tablet
Atcotibine
Indication
For the management of hypertension.
Atcotibine
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Atcotibine
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Atcotibine
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Atcotibine
Patient Information
Atcotibine
Organisms Affected
Humans and other mammals