Nicotibina
Brand names,
Nicotibina
Analogs
Nicotibina
Brand Names Mixture
Nicotibina
Chemical_Formula
C19H24N2O3
Nicotibina
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nicotibina
fda sheet
Nicotibina
msds (material safety sheet)
Nicotibina
Synthesis Reference
No information avaliable
Nicotibina
Molecular Weight
328.406 g/mol
Nicotibina
Melting Point
195-196 oC
Nicotibina
H2O Solubility
20 mg/ml (HCl salt)
Nicotibina
State
Solid
Nicotibina
LogP
2.868
Nicotibina
Dosage Forms
Liquid; Tablet
Nicotibina
Indication
For the management of hypertension.
Nicotibina
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nicotibina
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Nicotibina
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Nicotibina
Patient Information
Nicotibina
Organisms Affected
Humans and other mammals