Nicotisan
Brand names,
Nicotisan
Analogs
Nicotisan
Brand Names Mixture
Nicotisan
Chemical_Formula
C19H24N2O3
Nicotisan
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Nicotisan
fda sheet
Nicotisan
msds (material safety sheet)
Nicotisan
Synthesis Reference
No information avaliable
Nicotisan
Molecular Weight
328.406 g/mol
Nicotisan
Melting Point
195-196 oC
Nicotisan
H2O Solubility
20 mg/ml (HCl salt)
Nicotisan
State
Solid
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LogP
2.868
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Dosage Forms
Liquid; Tablet
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Indication
For the management of hypertension.
Nicotisan
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Nicotisan
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Nicotisan
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Nicotisan
Patient Information
Nicotisan
Organisms Affected
Humans and other mammals