Isonicotinylhydrazine
Brand names,
Isonicotinylhydrazine
Analogs
Isonicotinylhydrazine
Brand Names Mixture
Isonicotinylhydrazine
Chemical_Formula
C19H24N2O3
Isonicotinylhydrazine
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinylhydrazine
fda sheet
Isonicotinylhydrazine
msds (material safety sheet)
Isonicotinylhydrazine
Synthesis Reference
No information avaliable
Isonicotinylhydrazine
Molecular Weight
328.406 g/mol
Isonicotinylhydrazine
Melting Point
195-196 oC
Isonicotinylhydrazine
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinylhydrazine
State
Solid
Isonicotinylhydrazine
LogP
2.868
Isonicotinylhydrazine
Dosage Forms
Liquid; Tablet
Isonicotinylhydrazine
Indication
For the management of hypertension.
Isonicotinylhydrazine
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinylhydrazine
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinylhydrazine
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinylhydrazine
Patient Information
Isonicotinylhydrazine
Organisms Affected
Humans and other mammals