Isotamine
Brand names,
Isotamine
Analogs
Isotamine
Brand Names Mixture
Isotamine
Chemical_Formula
C19H24N2O3
Isotamine
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isotamine
fda sheet
Isotamine
msds (material safety sheet)
Isotamine
Synthesis Reference
No information avaliable
Isotamine
Molecular Weight
328.406 g/mol
Isotamine
Melting Point
195-196 oC
Isotamine
H2O Solubility
20 mg/ml (HCl salt)
Isotamine
State
Solid
Isotamine
LogP
2.868
Isotamine
Dosage Forms
Liquid; Tablet
Isotamine
Indication
For the management of hypertension.
Isotamine
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isotamine
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isotamine
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isotamine
Patient Information
Isotamine
Organisms Affected
Humans and other mammals