Cotinizin
Brand names,
Cotinizin
Analogs
Cotinizin
Brand Names Mixture
Cotinizin
Chemical_Formula
C19H24N2O3
Cotinizin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Cotinizin
fda sheet
Cotinizin
msds (material safety sheet)
Cotinizin
Synthesis Reference
No information avaliable
Cotinizin
Molecular Weight
328.406 g/mol
Cotinizin
Melting Point
195-196 oC
Cotinizin
H2O Solubility
20 mg/ml (HCl salt)
Cotinizin
State
Solid
Cotinizin
LogP
2.868
Cotinizin
Dosage Forms
Liquid; Tablet
Cotinizin
Indication
For the management of hypertension.
Cotinizin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Cotinizin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Cotinizin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Cotinizin
Patient Information
Cotinizin
Organisms Affected
Humans and other mammals