Isonide
Brand names,
Isonide
Analogs
Isonide
Brand Names Mixture
Isonide
Chemical_Formula
C19H24N2O3
Isonide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonide
fda sheet
Isonide
msds (material safety sheet)
Isonide
Synthesis Reference
No information avaliable
Isonide
Molecular Weight
328.406 g/mol
Isonide
Melting Point
195-196 oC
Isonide
H2O Solubility
20 mg/ml (HCl salt)
Isonide
State
Solid
Isonide
LogP
2.868
Isonide
Dosage Forms
Liquid; Tablet
Isonide
Indication
For the management of hypertension.
Isonide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonide
Patient Information
Isonide
Organisms Affected
Humans and other mammals