Hidranizil
Brand names,
Hidranizil
Analogs
Hidranizil
Brand Names Mixture
Hidranizil
Chemical_Formula
C19H24N2O3
Hidranizil
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Hidranizil
fda sheet
Hidranizil
msds (material safety sheet)
Hidranizil
Synthesis Reference
No information avaliable
Hidranizil
Molecular Weight
328.406 g/mol
Hidranizil
Melting Point
195-196 oC
Hidranizil
H2O Solubility
20 mg/ml (HCl salt)
Hidranizil
State
Solid
Hidranizil
LogP
2.868
Hidranizil
Dosage Forms
Liquid; Tablet
Hidranizil
Indication
For the management of hypertension.
Hidranizil
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Hidranizil
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Hidranizil
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Hidranizil
Patient Information
Hidranizil
Organisms Affected
Humans and other mammals