Isidrina
Brand names,
Isidrina
Analogs
Isidrina
Brand Names Mixture
Isidrina
Chemical_Formula
C19H24N2O3
Isidrina
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isidrina
fda sheet
Isidrina
msds (material safety sheet)
Isidrina
Synthesis Reference
No information avaliable
Isidrina
Molecular Weight
328.406 g/mol
Isidrina
Melting Point
195-196 oC
Isidrina
H2O Solubility
20 mg/ml (HCl salt)
Isidrina
State
Solid
Isidrina
LogP
2.868
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Dosage Forms
Liquid; Tablet
Isidrina
Indication
For the management of hypertension.
Isidrina
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isidrina
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isidrina
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isidrina
Patient Information
Isidrina
Organisms Affected
Humans and other mammals