Isonicotinohydrazide
Brand names,
Isonicotinohydrazide
Analogs
Isonicotinohydrazide
Brand Names Mixture
Isonicotinohydrazide
Chemical_Formula
C19H24N2O3
Isonicotinohydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinohydrazide
fda sheet
Isonicotinohydrazide
msds (material safety sheet)
Isonicotinohydrazide
Synthesis Reference
No information avaliable
Isonicotinohydrazide
Molecular Weight
328.406 g/mol
Isonicotinohydrazide
Melting Point
195-196 oC
Isonicotinohydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinohydrazide
State
Solid
Isonicotinohydrazide
LogP
2.868
Isonicotinohydrazide
Dosage Forms
Liquid; Tablet
Isonicotinohydrazide
Indication
For the management of hypertension.
Isonicotinohydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinohydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinohydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinohydrazide
Patient Information
Isonicotinohydrazide
Organisms Affected
Humans and other mammals