Hydrazid
Brand names,
Hydrazid
Analogs
Hydrazid
Brand Names Mixture
Hydrazid
Chemical_Formula
C19H24N2O3
Hydrazid
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Hydrazid
fda sheet
Hydrazid
msds (material safety sheet)
Hydrazid
Synthesis Reference
No information avaliable
Hydrazid
Molecular Weight
328.406 g/mol
Hydrazid
Melting Point
195-196 oC
Hydrazid
H2O Solubility
20 mg/ml (HCl salt)
Hydrazid
State
Solid
Hydrazid
LogP
2.868
Hydrazid
Dosage Forms
Liquid; Tablet
Hydrazid
Indication
For the management of hypertension.
Hydrazid
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Hydrazid
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Hydrazid
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Hydrazid
Patient Information
Hydrazid
Organisms Affected
Humans and other mammals