Isonicotinic acid hydrazide
Brand names,
Isonicotinic acid hydrazide
Analogs
Isonicotinic acid hydrazide
Brand Names Mixture
Isonicotinic acid hydrazide
Chemical_Formula
C19H24N2O3
Isonicotinic acid hydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonicotinic acid hydrazide
fda sheet
Isonicotinic acid hydrazide
msds (material safety sheet)
Isonicotinic acid hydrazide
Synthesis Reference
No information avaliable
Isonicotinic acid hydrazide
Molecular Weight
328.406 g/mol
Isonicotinic acid hydrazide
Melting Point
195-196 oC
Isonicotinic acid hydrazide
H2O Solubility
20 mg/ml (HCl salt)
Isonicotinic acid hydrazide
State
Solid
Isonicotinic acid hydrazide
LogP
2.868
Isonicotinic acid hydrazide
Dosage Forms
Liquid; Tablet
Isonicotinic acid hydrazide
Indication
For the management of hypertension.
Isonicotinic acid hydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonicotinic acid hydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonicotinic acid hydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonicotinic acid hydrazide
Patient Information
Isonicotinic acid hydrazide
Organisms Affected
Humans and other mammals