Hydrazide
Brand names,
Hydrazide
Analogs
Hydrazide
Brand Names Mixture
Hydrazide
Chemical_Formula
C19H24N2O3
Hydrazide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Hydrazide
fda sheet
Hydrazide
msds (material safety sheet)
Hydrazide
Synthesis Reference
No information avaliable
Hydrazide
Molecular Weight
328.406 g/mol
Hydrazide
Melting Point
195-196 oC
Hydrazide
H2O Solubility
20 mg/ml (HCl salt)
Hydrazide
State
Solid
Hydrazide
LogP
2.868
Hydrazide
Dosage Forms
Liquid; Tablet
Hydrazide
Indication
For the management of hypertension.
Hydrazide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Hydrazide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Hydrazide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Hydrazide
Patient Information
Hydrazide
Organisms Affected
Humans and other mammals