Cotinazin
Brand names,
Cotinazin
Analogs
Cotinazin
Brand Names Mixture
Cotinazin
Chemical_Formula
C19H24N2O3
Cotinazin
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Cotinazin
fda sheet
Cotinazin
msds (material safety sheet)
Cotinazin
Synthesis Reference
No information avaliable
Cotinazin
Molecular Weight
328.406 g/mol
Cotinazin
Melting Point
195-196 oC
Cotinazin
H2O Solubility
20 mg/ml (HCl salt)
Cotinazin
State
Solid
Cotinazin
LogP
2.868
Cotinazin
Dosage Forms
Liquid; Tablet
Cotinazin
Indication
For the management of hypertension.
Cotinazin
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Cotinazin
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Cotinazin
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Cotinazin
Patient Information
Cotinazin
Organisms Affected
Humans and other mammals