Isonirit
Brand names,
Isonirit
Analogs
Isonirit
Brand Names Mixture
Isonirit
Chemical_Formula
C19H24N2O3
Isonirit
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonirit
fda sheet
Isonirit
msds (material safety sheet)
Isonirit
Synthesis Reference
No information avaliable
Isonirit
Molecular Weight
328.406 g/mol
Isonirit
Melting Point
195-196 oC
Isonirit
H2O Solubility
20 mg/ml (HCl salt)
Isonirit
State
Solid
Isonirit
LogP
2.868
Isonirit
Dosage Forms
Liquid; Tablet
Isonirit
Indication
For the management of hypertension.
Isonirit
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonirit
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonirit
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonirit
Patient Information
Isonirit
Organisms Affected
Humans and other mammals