Isonizide
Brand names,
Isonizide
Analogs
Isonizide
Brand Names Mixture
Isonizide
Chemical_Formula
C19H24N2O3
Isonizide
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Isonizide
fda sheet
Isonizide
msds (material safety sheet)
Isonizide
Synthesis Reference
No information avaliable
Isonizide
Molecular Weight
328.406 g/mol
Isonizide
Melting Point
195-196 oC
Isonizide
H2O Solubility
20 mg/ml (HCl salt)
Isonizide
State
Solid
Isonizide
LogP
2.868
Isonizide
Dosage Forms
Liquid; Tablet
Isonizide
Indication
For the management of hypertension.
Isonizide
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Isonizide
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Isonizide
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Isonizide
Patient Information
Isonizide
Organisms Affected
Humans and other mammals