Ebidene
Brand names,
Ebidene
Analogs
Ebidene
Brand Names Mixture
Ebidene
Chemical_Formula
C19H24N2O3
Ebidene
RX_link
http://www.rxlist.com/cgi/generic2/labet.htm
Ebidene
fda sheet
Ebidene
msds (material safety sheet)
Ebidene
Synthesis Reference
No information avaliable
Ebidene
Molecular Weight
328.406 g/mol
Ebidene
Melting Point
195-196 oC
Ebidene
H2O Solubility
20 mg/ml (HCl salt)
Ebidene
State
Solid
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LogP
2.868
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Dosage Forms
Liquid; Tablet
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Indication
For the management of hypertension.
Ebidene
Pharmacology
Labetalol is an alpha-1 and beta adrenergic blocker used to treat high blood pressure. It works by blocking these adrenergic receptors, which slows sinus heart rate, decreases peripheral vascular resistance, and decreases cardiac output.
Ebidene
Absorption
Completely absorbed (100%) from the gastrointestinal tract with peak plasma levels occurring 1 to 2 hours after oral administration. The absolute bioavailability of labetalol is increased when administered with food.
Ebidene
side effects and Toxicity
LD50 = 66 mg/kg (Rat, IV). Side effects or adverse reactions include dizziness when standing up, very low blood pressure, severely slow heartbeat, weakness, diminished sexual function, fatigue
Ebidene
Patient Information
Ebidene
Organisms Affected
Humans and other mammals